Both players were hurt on the same drive.
Jackson is expected miss four to six weeks with a broken hand. With the regular season opener four weeks away, it is possible Jackson could miss time in the regular season.
Lynch is expected to miss three to four weeks with a sprained ankle. He should be back in time to start the first week of the season.
With both players hurt, rookie CJ Spiller will handle the carries for the rest of the preseason.
Tags: Buffalo Bills, NFL