As previously alluded to, Senior Prank Night is coming up on The Vampire Diaries and it will have a major impact on Matt. His issues with the supernatural world will finally boil over. Executive producer Julie Plec revealed that they will explore the sense of life he has lost over the course of the season. She also confirmed that he will have sex before the season is over.
Also, look for Klaus to get Stefan to completely close himself off emotionally making him one of the lead villains on the series.