The New York Daily News recently spoke with Chloe Sevigny (Melinda and Melinda) who said that she would love to have a role in Spider-Man 3 In doing so, she may have dropped a minor bomb-shell about who the villain will be in the third film.
“I’d love to be in ‘Spider-Man 3’! There’s a villain in it who’s a blond, buxom girl, and I’m trying to get it!” she told the paper.
Everything is speculation at this point. She could have meant that the studio is currently casting a role of Black Cat, which best matches her description of the character.